EPHB4 polyclonal antibody
产品名称： EPHB4 polyclonal antibody
英文名称： EPHB4 polyclonal antibody
产品编号： PAB3022
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152
- 传真 : +886-2-8751-1186
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of EPHB4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human EPHB4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:1000)
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.
Steinle JJ, Meininger CJ, Forough R, Wu G, Wu MH, Granger HJ.J Biol Chem. 2002 Nov 15;277(46):43830-5. Epub 2002 Sep 13.
- 2.
- A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis.
Suenobu S, Takakura N, Inada T, Yamada Y, Yuasa H, Zhang XQ, Sakano S, Oike Y, Suda T.Biochem Biophys Res Commun. 2002 May 10;293(3):1124-31.
- 3.
- Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells.
Wang Z, Miura N, Bonelli A, Mole P, Carlesso N, Olson DP, Scadden DT.Blood. 2002 Apr 15;99(8):2740-7.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with EPHB4 polyclonal antibody (Cat # PAB3022) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- ELISA
- Entrez GeneID:
- 2050
- Protein Accession#:
- P54760
- Gene Name:
- EPHB4
- Gene Alias:
- HTK,MYK1,TYRO11
- Gene Description:
- EPH receptor B4
- Omim ID:
- 600011
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq
- Other Designations:
- ephrin receptor EphB4,hepatoma transmembrane kinase,soluble EPHB4 variant 1,soluble EPHB4 variant 2,soluble EPHB4 variant 3
- Gene Pathway
- Related Disease