MCM4 purified MaxPab mouse polyclonal antibody (B01P)
产品名称： MCM4 purified MaxPab mouse polyclonal antibody (B01P)
英文名称： MCM4 purified MaxPab mouse polyclonal antibody (B01P)
产品编号： H00004173-B01P
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152
- 传真 : +886-2-8751-1186
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human MCM4 protein.
- Immunogen:
- MCM4 (AAH31061.1, 1 a.a. ~ 863 a.a) full-length human protein.
- Sequence:
- MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Tissue lysate)
- MCM4 MaxPab polyclonal antibody. Western Blot analysis of MCM4 expression in human placenta.
- Protocol Download
- Western Blot (Cell lysate)
- MCM4 MaxPab polyclonal antibody. Western Blot analysis of MCM4 expression in HeLa.
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of MCM4 expression in transfected 293T cell line (H00004173-T01) by MCM4 MaxPab polyclonal antibody.
Lane 1: MCM4 transfected lysate(94.93 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of purified MaxPab antibody to MCM4 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]
- Protocol Download
- Immunofluorescence
enlarge this image- Immunofluorescence of purified MaxPab antibody to MCM4 on HeLa cell. [antibody concentration 10 ug/ml]
- Protocol Download
- Entrez GeneID:
- 4173
- GeneBank Accession#:
- BC031061
- Protein Accession#:
- AAH31061.1
- Gene Name:
- MCM4
- Gene Alias:
- CDC21,CDC54,MGC33310,P1-CDC21,hCdc21
- Gene Description:
- minichromosome maintenance complex component 4
- Omim ID:
- 602638
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq
- Other Designations:
- DNA replication licensing factor MCM4,MCM4 minichromosome maintenance deficient 4,homolog of S. pombe cell devision cycle 21,minichromosome maintenance deficient 4
- Gene Pathway